| 雷帕霉素抑制肿瘤血管生成的研究进展 |
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| 引用本文： | 任传增,许戈良,荚卫东. 雷帕霉素抑制肿瘤血管生成的研究进展[J]. 国际外科学杂志, 2007, 34(8): 547-549 |
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| 作者姓名： | 任传增 许戈良 荚卫东 |
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| 作者单位： | 230001,合肥,安徽医科大学附属省立医院普外科;230001,合肥,安徽医科大学附属省立医院普外科;230001,合肥,安徽医科大学附属省立医院普外科 |
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| 基金项目： | 安徽省自然科学基金资助项目（No.050430711） |
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| 摘 要： | 实体瘤的生长和转移与血管生成密切相关，抑制肿瘤血管生成可作为控制肿瘤的重要手段。最近研究表明免疫抑制剂雷帕霉素具有抗肿瘤血管生成作用，这种作用可能与抑制血管内皮细胞增殖与迁移，减少促血管生成因子释放及促进肿瘤血管血栓形成等有关。对雷帕霉素抗肿瘤血管生成作用的深入研究可使其不仅作为一种免疫抑制剂，还可作为一种抗肿瘤药物应用于临床。现就雷帕霉素抑制肿瘤血管生成的可能机制作一综述。
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| 关 键 词： | 雷帕霉素 血管生成 免疫抑制剂 肿瘤 |
| 修稿时间： | 2007-04-13 |
Progress of rapamycin on anti-angiogenesis |
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| REN Chuan-Zeng,XU Ge-Liang,JIA Wei-Dong. Progress of rapamycin on anti-angiogenesis[J]. International Journal of Surgery, 2007, 34(8): 547-549 |
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| Authors: | REN Chuan-Zeng XU Ge-Liang JIA Wei-Dong |
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| Affiliation: | Department of General Surgery, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China |
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| Abstract: | Tumors growth and metastasis are associated closely with angiogenesis, and anti-angiogenesis can be considered as an effective target for controlling tumors. Recent studies reveal that antiangiogenic effect of rapamycin may be related to inhibiting proliferation and migration of vascular endothelial cells, de- creasing proangiogenic factors, and inducing thrombosis. Further study on the potential mechanisms of rapa- mycin on anti-angiogenesis can develop it not only as an immunosuppressor but also as a new antitumor drug for clinical application. |
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| Keywords: | rapamycin angiogenesis immunosuppressor tumor |
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