平阳霉素硬化治疗11例婴幼儿唇部血管瘤疗效分析

目的：评价平阳霉素（Pingyangmycin，PYM）硬化治疗婴幼儿唇部血管瘤的疗效。方法：采用平阳霉素瘤内注射治疗婴幼儿唇部血管瘤11例，一次注射不能治愈者，隔周重复注射1次，最多3次为1疗程。记录患儿的全身和局部不良反应，追踪随访1-2．5a，观察临床疗效。结果：11例患儿全部治愈，其中注射1次6例，注射2次4例，注射3次1例。最初治疗的3例均出现局部溃疡，改进注射方法和剂量治疗8例，无1例发生溃疡。观察1-2．5a，发生溃疡部位未见瘢痕形成，无一例复发。注射后局部不良反应包括肿胀，全身不良反应包括低热（5例）和食欲下降（2例）。无一例出现过敏反应。结论：平阳霉素瘤内注射治疗婴幼儿唇部血管瘤治愈率高，疗程较短。但使用时需注意注射剂量，避免发生局部溃疡。

Treatment of infantile hemangioma located in the lip with intralesional injection of Pingyangmycin

PURPOSE： To investigate a safe and effective method to treat infantile hemangioma in the lip with Pingyangmycin （PYM） sclerotherapy and evaluate its clinical efficacy. METHODS： Eleven patients were treated by intralesional injection of PYM. When necessary, the injections were repeated at an interval of one week, but not more than 3 sessions. The general and local adverse responses were recorded and the clinical outcomes were assessed with a follow-up period from 1 to 2.5 years. RESULTS： Complete clinical resolution was achieved in all patients. Six patients received one injection, 4 patients received 2 injections, and the remaining received 3 injections. Three patients initially treated had mucosal necrosis. After adjusting the drug dosage, eight patients subsequently treated did not develop necrosis. No clinical recurrence or scar was observed during the follow-up period. Transient local swelling occurred in almost all patients. The systematic complications included transient pyrexia in 5 patients and poor appetite in 2 patients. No allergy was found. CONCLUSIONS： Treatment of infantile hemangioma in the lip with PYM sclerotherapy has a high rate of complete resolution and a short treatment time. The dosage of the sclerosant should be appropriate to avoid post-injective necrosis.