乙型肝炎病毒基因型与病情轻重的关系

目的研究乙型肝炎病毒(HBV)基因型与肝脏损伤程度的相关性。方法随机选取87例慢性无症状乙型肝炎表面抗原携带者(ASC)、157例慢性乙型肝炎(CHB)、22例肝硬化(LC)和18例肝细胞癌(HCC)患者外周血测定HBV S基因序列以明确其基因型。结果基因型以B型和C型为主,分别为26.1％和73.2％。在B型与C型中,ASC、CHB、LC和HCC的构成比差异有非常显著性(X2=15.09,P<0.001),C型与B型相比,C型发展致CHB和HCC所占百分比显著高于B型,分别为59.6％比43.2％,X2=10.87,P<0.001;和7.7％比1.4％,X2=7.41,P<0.001。而LC所占百分比差异无显著性。结论基因型C型与B型相比,C型HBV感染易引起较重肝脏损伤。

Relationship between the genotypes of hepatitis B virus and the severity of liver diseases

Objective To investigate the relationship between different geontypes of hepatitis B virus (HBV) and the severity of liver diseases. Methods The S nucleotide sequences of HBV strains isolated from plasma samples of 284 patients were detected and compared. Among them, 87 patients were HBV asymptomatic carriers (ASC), 157 chronic hepatitis B (CHB), 22 liver cirrhosis (LC) ,and 18 hepatocellular carcinoma (HCC). Results Genotypes B and C were predominant, with a 26.1% proportion and a 63.2% proportion respectively. The percents of genotypes B and C in patients with ASC, CHB, LC, and HCC were significantly different (x2=15.09, P<0.001). Compared with genotype B, genotype C was more common in patients with CHB and HCC (59.6% vs 43.2%, xj=10.87, P<0.001; 7.7% vsl.4%, x2=7.41, P<0.001), but in patients with LC there was no different (7.7% vs 8.1%, x2=1.29, P>0.05). Conclusions This study suggests that genotype B and C are predominant. And genotype C may induce more severe the liver inflammation than genotype B may do.