Weight and Body Mass Index at Menarche are Associated with Premenopausal Bone Mass |
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Authors: | M Blum S S Harris A Must S M Phillips W M Rand B Dawson-Hughes |
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Institution: | (1) Calcium and Metabolic Bone Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University;, US;(2) Department of Family Medicine and Community Health, Tufts University, Boston, Massachusetts, USA, US |
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Abstract: | Adolescence is a critical time for skeletal growth and mineralization. Exposure to protective or detrimental factors during
this period may influence peak bone mass attainment and subsequent development of osteoporosis. In order to evaluate the association
of body size during adolescence with subsequent adult bone mass, we conducted a follow-up study of a community-based cohort
of girls who participated in a growth and sexual maturation study 30 years ago. Data from the original study included age
at menarche, height at menarche and weight at menarche. Follow-up evaluation of 119 subjects, now premenopausal women ages
40–45 years, included bone mineral density (BMD) measurements of the total body, lumbar spine, femoral neck, total hip, and
ultradistal radius by dual-energy X-ray absorptiometry. After adjustment for current adult weight and other factors related
to bone mass, weight at menarche was found to be positively associated with subsequent adult BMD. Similarly, body mass index
(BMI) at menarche was positively associated with adult BMD. In contrast, age at menarche was not found to predict adult BMD.
When the subjects were divided into quartiles based on their BMI at menarche, subjects in the lowest quartile of BMI at menarche
had adult mean BMD that was 8–15% lower at the measured sites compared with subjects in the highest quartile of BMI at menarche.
In conclusion, low body weight and low BMI at menarche appear to be significant predictors of reduced bone mass in healthy
premenopausal women ages 40–45 years.
Received: 15 August 2000 / Accepted: 2 January 2001 |
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Keywords: | :Adolescence – Body mass index – Bone mass – Menarche – Weight |
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