| 氯化锂对小鼠生殖和胚泡细胞遗传毒性的研究 |
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| 引用本文： | 帕它木,黄贤仪.氯化锂对小鼠生殖和胚泡细胞遗传毒性的研究[J].劳动医学,1999,16(2):70-72. |
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| 作者姓名： | 帕它木 黄贤仪 |
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| 作者单位： | 新疆医科大学劳动卫生学教研室 |
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| 摘 要： | 目的：观察氯化锂的遗传毒性特征并对其毒作用机制做一切初步探讨。方法：以氯化锂为受试物，昆明种小鼠为受试对象，进行小鼠生殖细胞遗传毒性试验。结果：氯化锂经口灌胃染毒后，小鼠睾丸细胞染色体畸变率增加，着床前胚泡细胞微核率增加，结论：一定剂量的氯化锂对小鼠生殖和胚泡细胞具有遗传性毒性用。
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| 关 键 词： | 氯化锂 生殖细胞 胚泡细胞 遗传毒性 |
Study on the Genotoxicity of Lithium Chloride to Germ and Embryocystic Cells in Mice |
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| PATAM,HUANG Xianyi,GONG Jianfu.Study on the Genotoxicity of Lithium Chloride to Germ and Embryocystic Cells in Mice[J].Journal of Labour Medicine,1999,16(2):70-72. |
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| Authors: | PATAM HUANG Xianyi GONG Jianfu |
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| Abstract: | Objective: To study the genotoxicity of lithium chloride and its mechanism in mice. Method: Genotoxicity to germ and embryocystic cells in Kunmin mice given lithium chloride by gavage was determined. Result: The frequency of chromosome aberrations of testis cells and micronuclei of preimplantation embryos increased(P<0.01,P<0.01). Conclusion: Lithium chloride might cause chromosome damage to germ and embryocystic cells in mice. |
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| Keywords: | lithium chloride germ cells embryocystic cells genotoxicity |
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