The role of isolated limb perfusion for melanoma confined to the extremities |
| |
| Authors: | Eggermont Alexander M M van Geel Albertus N de Wilt Johannes H W ten Hagen Timo L M |
| |
| Affiliation: | Department of Surgical Oncology, Erasmus University Medical Center, Rotterdam-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. eggermont@chih.azr.nl |
| |
| Abstract: | ![]()
Isolated limb perfusion with Melphalan is the best treatment option to control symptomatic multiple small in-transit metastases. When lesions are bulky, Isolated Limb Perfusion (ILP) with Tumor Necrosis Factor (TNF) + Melphalan is superior as in soft tissue sarcoma. TNF changes the pathophysiology, greatly enhances the uptake of Melphalan and destructs selectively the vasculature of large tumors. To date, ILP is not indicated in an adjuvant setting. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
