放疗导致心脏损伤的发生机制及防治进展

摘要：放疗作为恶性肿瘤的主要治疗方法之一,广泛应用于乳腺癌、食管癌、肺癌、纵隔肿瘤和淋巴瘤等疾病。接受放疗患者长时间在X线照射下很容易导致心脏损伤,引起不同程度的放射性心脏病（RIHD）,RIHD可以破坏心脏的任何结构,因此心脏损伤在癌症幸存者中成为危及生命的疾病,而有效的临床管理及防治仍然具有很大的挑战性。本文对放疗后心脏损伤的表现、发生机制、心脏相关指标监测及防治进展等方面作一综述。

The mechanism of cardiac injury induced by radiotherapy and itsprogress of prevention and treatment

Abstract: Radiotherapy is one of the main treatments for malignant tumors, and is widely used today, such as breastcancer, esophageal cancer, lung cancer, mediastinal tumors, and Hodgkin's disease. Patients undergoing radiotherapy aresusceptible heart damage of prolonged periods of X-ray irradiation for a long time, causing varying degrees of radiologicalheart disease (RIHD). RIHD may involve any structure of heart, so cardiac complications become life-threatening diseases incancer survivors. The effective clinical management and prevention are still quite challenging. This article reviews themanifestation, pathogenesis, monitoring of cardiac related indexes and progressin prevention and treatment of cardiac injuryin patients after radiotherapy.