肺癌静脉血栓栓塞的危险因素及生物标志物的研究进展

癌症是引起静脉血栓栓塞(venous thromboembolism,VTE)的重要危险因素，而VTE是引起肿瘤患者死亡的重要原因。肺癌患者VTE的发生率在不同的研究中结果有所差别，发生率从7%~13%不等，其中还包括大量可疑肺栓塞病例。肺癌患者VTE发生的危险因素可以分为三类:患者自身特征、肿瘤相关因素以及治疗相关的因素。此外，许多生物标志物也被发现可以作为VTE发生的危险因素(例如D-二聚体)。了解肺癌VTE发生的危险因素对于预防血栓并发症的发生、改善肺癌患者的治疗方面具有重要的意义。本文就VTE危险因素及生物标志物进行综述。

Venous thromboembolism and lung cancer:A systematic review in risk factors and biomarkers

Cancer is a critical risk factor for venous thromboembolism(VTE),and VTE plays an important role in cancer-related death.The incidence of VTE in lung cancer patients varies in previous studies,ranging 7%～13%.The risk factors of VTE in lung cancer patients can be divided into three categories:The patients' own characteristics,tumor-related factors and treatment-related factors.In addition,many biomarkers have also been demonstrated to be risk factors of VTE(eg,D-dimer).The identification of risk factors of VTE in lung cancer is of great value in preventing the occurrence of thrombotic complications and improving the treatment of lung cancer patients.In this review,we will mainly focus on the risk factors and biomarkers of lung cancer patients with VTE.