郑州大学生存质量量表在218例口腔癌患者术后生存质量评估中的应用评价

目的: 分析郑州大学生存质量量表在评估口腔癌患者术后3~6个月生存质量中的最佳阈值。方法: 对符合纳入标准的218例口腔癌患者进行问卷调查,由患者填写郑州大学生存质量量表和华盛顿大学生存质量量表,共回收有效问卷178份,回收率81.65%。以华盛顿大学生存质量量表作为“金标准”,绘制受试者工作特征曲线（ROC曲线）,确定郑州大学生存质量量表的最佳阈值。应用SPSS 20.0软件包进行数据分析,分别采用Spearman-Brown相关分析和ROC曲线对量表进行分析。结果: 郑州大学生存质量量表总得分与华盛顿大学生存质量量表总分之间呈中度正相关（r=0.685,P<0.05）。当郑州大学生存质量量表阈值取55.682分时,ROC曲线距离左上角最近,此时敏感度、特异度、假阴性率、假阳性率及约登指数分别为0.797、0.676、0.203、0.324和0.473,ROC曲线下面积为0.809,面积的标准误为0.047,95%CI为0.718~0.901;当阈值取整数时为56分。结论: 郑州大学生存质量量表在口腔癌患者术后3~6个月的生存质量评估中的最佳阈值为56分,可作为口腔癌患者术后生存质量评估及筛查的参考依据。

Use of Zhengzhou University-quality of life scale in 218 postoperative patients with oral cancer

PURPOSE: The purpose of this study was to explore the best threshold of Zhengzhou University-quality of life(ZZU-QOL) scale in patients with oral cancer 3 to 6 months after operation. METHODS: A questionnaire survey was conducted on 218 patients with oral cancer who met the inclusion criteria. The patients were asked to fill in the ZZU-QOL and the University of Washington Quality of Life Scale(UWQOL). A total of 178 valid questionnaires were collected and the recovery rate was 81.65%. The UWQOL was used as "the gold standard", and the receiver operating characteristic curve (ROC) was drawn to determine the optimal threshold of quality of life scale of Zhengzhou University. Statistical analysis was performed by using SPSS 20 software package. RESULTS: There was a moderate positive correlation between total score of quality of life scale of Zhengzhou University and the total score of the UWQOL (r=0.685, P<0.05). When the ZZU-QOL threshold was 55.682, ROC curve was closest to the upper left corner, its sensitivity and specificity, false negative rate, false positive rate and Youden index were 0.797, 0.676, 0.203, 0.324 and 0.473, respectively. The area under the ROC curve was 0.809, the standard error of the area was 0.047, the 95% confidence interval was 0.718 - 0.901, and the threshold was 56 when the integer was taken. CONCLUSIONS: The optimal threshold of ZZU-QOL in oral cancer patients 3 to 6 months after operation was 56 points, which may be used as the theoretical guidance and basis for evaluation and screening of postoperative quality of life in patients with oral cancer.