同步辐射衍射增强成像技术检测人离体乳腺癌的实验研究

背景与目的：同步辐射衍射增强成像(diffraction-enhanced imaging，DEI)是近年来发展起来的新技术，具有极高的软组织分辨率，比传统X线吸收成像分辨率高1 000倍。该研究旨在探讨DEI技术在人离体乳腺癌标本中的应用。方法：15例乳腺癌标本经4%甲醛溶液固定后，在北京同步辐射装置（Beijing synchrotron radiation facility，BSRF）的4W1A束线X射线成像站进行同步辐射DEI，最后行病理学检查，将所得影像学资料与病理学资料进行对比研究。结果：15例标本均获得了良好的衍射增强图像，均可清晰地显示病变组织与正常组织，其中3例标本中可见钙化灶，同一样品在摇摆曲线不同位置获得不同的图像，所有的衍射增强图像均具有较高的空间分辨率和衬度分辨率。结论：同步辐射DEI技术具有很高的衬度分辨率和空间分辨率，可清晰观察肿瘤内部组织特征和空间分布，而且其采用的折射成像机制，可以有效地减少X射线对人体的辐射损伤，具有良好的基础医学应用前景。

Experimental study on detection of human breast cancer by diffraction-enhanced imaging

Background and purpose: Diffraction-enhanced imaging (DEI) is a recently developed imaging technique, which is approximately 1 000 times more sensitive than conventional absorption contrast imaging when imaging the soft tissue. The aim of this study was to evaluate the application of the synchrotron radiation DEI in human breast cancer. Methods: Fifteen excised human breast specimens were studied. Monochromatic synchrotron radiation DEI was obtained at the beamline 4W1A of the Beijing synchrotron radiation facility in China with the energy of 15keV. Finally, the pathology results were confirmed. Results: Good DEI of the 15 samples were all obtained. The imaging clearly showed the lesions and the normal tissue. The images obtained with DEI had higher contrast and better resolution. Conclusion: Synchrotron radiation diffraction enhanced imaging can detect the characteristics and spatial distribution of human breast cancer, and its use of refraction imaging mechanism can effectively reduce the radiation damage of X-ray on the human body. It would be a great potential diagnostic tool in clinical application in the future.