| MYC抑制剂与小细胞肺癌关系的研究进展MYC抑制剂与小细胞肺癌关系的研究进展 |
| |
| 引用本文： | 刘 佳1,张淑君2,成秉林1. MYC抑制剂与小细胞肺癌关系的研究进展MYC抑制剂与小细胞肺癌关系的研究进展[J]. 现代肿瘤医学, 2018, 0(2): 288-290. DOI: 10.3969/j.issn.1672-4992.2018.02.033 |
| |
| 作者姓名： | 刘 佳1 张淑君2 成秉林1 |
| |
| 作者单位： | 1.哈尔滨医科大学附属第一医院中西医结合肿瘤科，黑龙江 哈尔滨 150000；2.哈尔滨医科大学附属第四医院病理科，黑龙江 哈尔滨 150000 |
| |
| 基金项目： | 黑龙江省自然科学基金面上项目(编号:H2015094)；哈医大一院科研创新基金(编号:2017Y001) |
| |
| 摘 要： | MYC在多种肿瘤中高表达，发挥重要的生物学作用，MYC抑制剂Omomyc可抑制MYC和其他基因或蛋白结合。Omomyc可停滞小细胞肺癌细胞的细胞周期，并促进细胞凋亡，机制与p21相关。本文综述MYC的概念和作用，总结MYC与肿瘤的关系，论述MYC抑制剂Omomyc的作用机制和研究进展，讨论Omomyc促小细胞肺癌细胞凋亡的作用机制与p21的相关性。MYC与肿瘤密切的关系使MYC抑制剂Omomyc的研究日益重要，本文旨在为临床治疗靶点提供新思路。
|
| 关 键 词： | MYC Omomyc 小细胞肺癌 |
Research progress on MYC inhibitor with small cell lung cancer |
| |
| Liu Jia1,Zhang Shujun2,Cheng Binglin1. Research progress on MYC inhibitor with small cell lung cancer[J]. Journal of Modern Oncology, 2018, 0(2): 288-290. DOI: 10.3969/j.issn.1672-4992.2018.02.033 |
| |
| Authors: | Liu Jia1 Zhang Shujun2 Cheng Binglin1 |
| |
| Affiliation: | 1.Department of Integrated Traditional Chinese and Western Medicine Oncology，the First Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150000，China；2.Department of Pathology，the Fourth Affiliated Hospital of Harbin Medical University，Heilongjiang Harbin 150000，China. |
| |
| Abstract: | YC plays an important biological role and the high expression of MYC may happen in a variety of tumors.MYC inhibitor Omomyc inhibits MYC bounding with other genes or proteins.Omomyc can stop small cell lung cancer cell cycle,induce apoptosis,the mechanism depends on p21.The objective of this article is to review concepts and functions of MYC,to summary the relationship of MYC and tumor,to discuss the mechanism and research progress of MYC inhibitor Omomyc,to explore the principle of Omomyc promoting apoptosis in small cell lung cancer cells and p21 correlation.Research on Omomyc may plays an important role on tumors because the close relationship between MYC and tumors.They play a more important role in clinical and therapeutic target. |
| |
| Keywords: | MYC Omomyc small cell lung cancer |
|
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载免费的PDF全文 |
