前列腺癌组织中Eya2的表达及临床意义

目的:分析Eya2在前列腺癌组织中的表达模式并分析其临床意义。方法:通过免疫组织化学方法检测76例前列腺癌组织以及4例正常前列腺组织中Eya2的蛋白表达量，并通过统计学方法探究其临床意义。结果:76例前列腺癌组织中47例Eya2表达上调，上调比例为61.8%。Eya2表达上调与肿瘤组织较高的Gleason评分显著相关。结论:前列腺癌组织中Eya2为促癌因子，表达量上调与较高的Gleason评分显著相关，可作为临床诊断的一个重要靶点。

The expression of Eya2 and its clinical significance in prostate cancer

Objective:To explore the expression pattern and clinical significance of Eya2 in prostate cancer.Methods:Immunohistochemistry was employed to detect the protein expression of Eya2 in 76 cases of prostate cancers and 4 cases of non-cancerous prostate tissues.Statistical method was used to analyze the clinical significance of Eya2 expression.Results:Eya2 was up-regulated in prostate cancers (47/76,61.8%).Eya2 expression was significantly associated with Gleason score of prostate cancer tissue.Conclusion:Eya2 was an oncogene and its protein expression was upregulated in prostate cancer.Eya2 high expression was significantly correlated with high Gleason score.Eya2 could be a target in clinic diagnose for prostate cancer.