TNF在动物多器官衰竭中的变化及意义

在动物多器官衰竭模型上动态观察肿瘤坏死因子变化，探讨ＴＮＦ与ＭＯＦ的内在联系。４０只家兔分为３组：Ａ组２０只，Ｂ，Ｃ组各１０只。Ａ组用失血性休克，内毒素复合因素复制出ＭＯＦ模型；Ｂ组仅给内毒素；Ｃ组仅施失血性休克。衰竭器官≥２个者诊断为ＭＯＦ，ＴＮＦ测定用生物法。

Changes of TNF in animal MOF and their significance

Objective: To observe the dynamic changes of tumor necrosis factor(TNF) in the animal MOF model and probe into the inner link of TNF and multi-organ failure(MOF). Methods: 40 rabbits were divided into 3 groups. As MOF models, 20 animals in group A were given the complex factors of hemorrhagic shock and endotoxin, 10 in group B only given endotoxin and 10 in group C only hemorrhagic shock. MOF was diagnosed if the numbers of the failure organs were 2 or more. TNF was tested by the use of the biomethod. Results : The morbidity of MOF in group A was 75%. The levels of TNF were up after hemorrhagic shock and endotoxin injection ,especially after endotoxin,in the group A; those in the MOF animals were higher than those in the nonMOF; those in the animals with 3 or more failure organs were much higher than those with 2; those in the animals that died within 36 h were distinctly higher than ones that died after 36 h. There was significant interrelationship between the levels of TNF and the functions of main organs, the morbidity of MOF, the number of failure organs, the living time and rate of animals, and so on. Conclusion: TNF may play an important role in the development of MOF.