| 血管老化机制与硫化氢的保护作用 |
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| 引用本文： | 侯翠兰.血管老化机制与硫化氢的保护作用[J].复旦学报(医学版),2016,43(2):249. |
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| 作者姓名： | 侯翠兰 |
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| 作者单位： | 1 复旦大学基础医学院生理与病理生理学系 上海 200032; 2 复旦大学老年医学研究中心 上海 200040 |
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| 基金项目： | 复旦大学老年医学研究中心项目 (13dz2260700) |
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| 摘 要： | 随着全球老龄化的到来,衰老及其相关疾病带来的健康问题日益严峻。血管老化包括血管结构和功能的改变,也是心血管疾病发生发展的重要因素,是机体衰老的一部分。目前科学家对血管老化机制的研究甚少,本文将从血管老化的分子机制和硫化氢的保护作用两个方面入手,综述了血管老化方面的最新进展。
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| 关 键 词： | 血管老化 硫化氢 端粒 非酶糖基化 氧化应激 表观遗传 |
| 收稿时间： | 2015-07-24 |
Mechanism of vascular aging and protective effects of hydrogen sulfide |
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| HOU Cui-lan,WANG Ming-jie,JIN Sheng,ZHU Yi-chun.Mechanism of vascular aging and protective effects of hydrogen sulfide[J].Fudan University Journal of Medical Sciences,2016,43(2):249. |
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| Authors: | HOU Cui-lan WANG Ming-jie JIN Sheng ZHU Yi-chun |
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| Institution: | 1 Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China; 2 Research Center on Aging and Medicine,Fudan University,Shanghai 200040,China |
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| Abstract: | With the arrival of global aging,the health problems from aging and age-related diseases are becoming more and more severe.Vascular aging includes changes in vascular structure and function,which plays an important role in the process of cardiovascular disease,and also is a vital part of the aging. However,the mechanism of vascular aging is poorly understood.This article contended the latest research progress in molecular mechanisms of vascular aging and protection of hydrogen sulfide. |
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| Keywords: | vascular aging hydrogen sulfide telomere non enzymatic glycosylation oxidative stress epigenetic |
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