微小残留病灶(MRD)监测在慢性淋巴细胞白血病(CLL)中的应用进展

 慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)是西方国家最常见的成人白血病,在我国的发病率也日益增加。近年来针对CLL的新药层出不穷,微小残留病灶(minimal residual disease,MRD)监测逐渐成为评估疗效的重要手段。本文总结了目前常用的MRD检测方法,包括流式细胞学和基于PCR法的分子学检测,并介绍了其在初治CLL疗效评价、预后评估和在移植后CLL复发预警方面的应用进展。

Progress of minimal residual disease (MRD) monitoring in chronic lymphocytic leukemia (CLL)

Chronic lymphocytic leukemia (CLL) is the commonest adult leukemia in Western countries.Recent years has witnessed an increasing incidence rate in China.Since new agents have been developed over the decades,minimal residual disease (MRD) monitoring became an efficient way to assess the treatment effect.Here we reviewed the common methods to test MRD including flow cytometry and molecular detection methods based on PCR technique.Also we introduced the progress of MRD monitoring in response and prognostic assessment in newly-treated CLL patients and early relapse detection in CLL patients after allogenic stem cell transplantation.