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| 早期改善在抗抑郁药治疗重度抑郁症(MDD)中的研究进展 | |
| 引用本文： | 袁心崧(综述),朱笑,施慎逊(审校). 早期改善在抗抑郁药治疗重度抑郁症(MDD)中的研究进展[J]. 复旦学报(医学版), 2019, 46(3): 414-419. DOI: 10.3969/j.issn.1672-8467.2019.03.021 |
| 作者姓名： | 袁心崧(综述) 朱笑 施慎逊(审校) |
| 作者单位： | 复旦大学附属华山医院精神医学科 上海 200040 |
| 摘 要： | 在第2周未达到早期改善(early improvement)的重度抑郁症(major depressive disorder,MDD)患者继续维持原治疗方案只有3%能达到临床治愈,但尽管早期改善有较高的阴性预测值,阳性预测值却不理想。本综述整理现有的研究中除了17项汉密尔顿抑郁量表总分的减分率外,还有哪些指标能判断早期改善,早期改善的预测效果受到什么因素影响,能否协同这些因素提高早期改善的预测效果。用以指导早期换药,降低患者接受无效治疗的时间,降低治疗费用,增加患者对治疗的信心。 |
| 关 键 词： | 早期改善 抗抑郁药 重度抑郁症(MDD) |
Advances in early improvement of antidepressants for treating major depressive disorder (MDD) |
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| YUAN Hsin-sung,ZHU Xiao,SHI Shen-xun. Advances in early improvement of antidepressants for treating major depressive disorder (MDD)[J]. Fudan University Journal of Medical Sciences, 2019, 46(3): 414-419. DOI: 10.3969/j.issn.1672-8467.2019.03.021 | |
| Authors: | YUAN Hsin-sung ZHU Xiao SHI Shen-xun |
| Affiliation: | Department of Psychiatry,Huashan Hostipal,Fudan University,Shanghai 200040,China |
| Abstract: | Early improvement in the first 2 weeks can only predict 3% non-remission in major depressive disorder (MDD) patients who continued the original treatment.However,the positive predictive value of early improvement was unsatisfactory despite of higher negative predictive value.This report provides an updated review about the indicators of early improvement and the influence factor of the predictive value of early improvement. |
| Keywords: | early improvement antidepressants major depressive disorder (MDD) |
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