服用小剂量他达那非对动脉性勃起功能障碍患者临床疗效的观察

目的:观察服用小剂量磷酸二酯酶-5(PDE5)抑制剂他达那非对动脉性勃起功能障碍(ED)患者的疗效。方法:对43例动脉性ED患者采用了疗程为4周的隔日小剂量(5 mg)晚餐后口服他达那非的用药方案,在治疗前后进行IIEF-5评分同时用彩色多普勒超声联合阴茎血管活性药物前列腺素(PGE-1)注射实验,检测阴茎双侧海绵体动脉的收缩期最大流速(PSV)。结果:经统计学分析,IIEF-5评分以及阴茎双侧海绵体动脉的PSV在治疗4周后有显著提高(P<0.05)。结论:口服小剂量他达那非能有效提高动脉性ED患者阴茎海绵体动脉的收缩期最大流速,改善患者的勃起质量。

Low-Dose Tadalafil Improves Arterial Erectile Dysfunction

Objective:To evaluate the effect of low-dose phosphodiesterase type 5 inhibitor tadalafil on aaefial erectile dysfunction.Methods:Fony-three patients with arterial erectile dysfunction were requested to take 5 mg tadalafil after supper on alternate days for 4 weeks.All the patients were scored on IIEF-5 and received intracavernous injection of 10 μg prostaglandin E1,followed by measurement of the peak systolic velocity(PSV)of the cavernosal artery by color Doppler ultrasonography. Results:Statistic analyses showed an obvious increase in the IIEF-5 score and PSV after the treatment,with significant differences from the baseline(P <0.01). Conclusion:Low-dose tadalafil can significantly improve the PSV of the cavernosal artery and hence the erectile function of arterial ED patients.