| 高压氧治疗重度闭合性颅脑创伤的疗效及依达拉奉的干预作用 |
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| 引用本文： | 蔡宏斌,葛朝明,赵翀翀,张兰芳,闫湘.高压氧治疗重度闭合性颅脑创伤的疗效及依达拉奉的干预作用[J].中国全科医学,2010,13(8):834-836. |
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| 作者姓名： | 蔡宏斌 葛朝明 赵翀翀 张兰芳 闫湘 |
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| 作者单位： | 兰州大学第二医院神经内科高压氧治疗中心,甘肃省兰州市,730000 |
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| 摘 要： | 目的 探讨高压氧(HBO)治疗重度闭合性颅脑损伤(TBI)患者的临床疗效和依达拉奉的干预作用.方法 42例TBI患者,随机分为两组,HBO治疗组21例,行HBO 和其他常规治疗;依达拉奉干预组(EB干预组)21例,在HBO 和其他常规治疗基础上加用依达拉奉;另选12例健康志愿者为正常对照组.于治疗前、治疗14 d后行格拉斯哥昏迷评分(GCS)并检测血清丙二醛(MDA)、蛋白质氧化硝基化指标3-硝基酪氨酸(3-nitrotynosine,3-NT)水平及抗氧化酶铜、锌离子超氧化物歧化酶(CuZn-superoxide dismutase,CuZn-SOD)和谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-px)的活力变化,病程3个月时行格拉斯哥预后评分(GOS).结果 治疗前HBO治疗组和EB干预组的GCS、血清MDA、3-NT水平及CuZn-SOD、GSH-px活力间差异无统计学意义(P＞0.05),但与正常对照组比较差异均有统计学意义(P＜0.01);而治疗后HBO治疗组和EB干预组上述各指标间差异均有统计学意义(P＜0.05),病程3个月时两组患者GOS间差别亦有统计学意义(P＜0.05).结论 依达拉奉联合HBO治疗重度闭合性TBI的疗效优于单纯HBO治疗.
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| 关 键 词： | 高压氧 依达拉奉 颅脑损伤 丙二醛 Cu-Zn超氧化物歧化酶 |
Clinical Evaluation of Hyperbaric Oxygenation in Severe Closed Traumatic Brain Injury and Effects of Edaravone |
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| CAIHong-bin,GEZhao-ming,ZHAOChong-chong,etal.HyperbaricOxygenTherapyCenter,SecondHospitalofLanzhouUniversity,Lanzhou,China.Clinical Evaluation of Hyperbaric Oxygenation in Severe Closed Traumatic Brain Injury and Effects of Edaravone[J].Chinese General Practice,2010,13(8):834-836. |
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| Authors: | CAIHong-bin GEZhao-ming ZHAOChong-chong etalHyperbaricOxygenTherapyCenter SecondHospitalofLanzhouUniversity Lanzhou China |
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| Institution: | CAI+Hong-bin,GE+Zhao-ming,ZHAO+Chong-chong,et+al.Hyperbaric+Oxygen+Therapy+Center,Second+Hospital+of+Lanzhou+University,Lanzhou730000,China |
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| Abstract: | Objective To observe the therapeutic effects of hyperbaric oxygenation (HBO) combined with edaravone,a potent scavenger of hydroxyl radicals,on severe closed traumatic brain injury(TBI).Methods Forty-two patients were randomized into groups HBO and HBO+EB (receiving treatment of HBO and edarayone),21 in each.Another 12 healthy volunteers were chosen as normal controls.Before treatment and after 14 d of treatment,Glasgow Coma Scores (GCS) were performed and Malondialdehyde(MDA),3-nitrnosine(3-NT),CuZn-supero... |
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| Keywords: | Hyperbaric oxygen Edaravone Craniocerebral trauma Malondialdehyde Cu-Zn superoxide dismutase |
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