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Burkitt's lymphoma in a patient with adenosine deaminase deficiency-severe combined immunodeficiency treated with polyethylene glycol-adenosine deaminase |
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| Authors: | Husain Maitham Grunebaum Eyal Naqvi Ahmed Atkinson Adelle Ngan Bo-Yee Aiuti Alessandro Roifman Chaim M |
| Affiliation: | Division of Immunology/Allergy, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada. |
| Abstract: | We describe a patient with severe combined immunodeficiency because of aberrations in adenosine deaminase (ADA) who despite adequate replacement with polyethylene glycol-linked ADA (PEG-ADA) for 13 years developed Burkitt's lymphoma. Although treatment corrected the metabolic abnormalities caused by ADA deficiency, it failed to fully restore cellular immunity. |
| Keywords: | ADA, Adenosine deaminase PEG-ADA, Polyethylene glycol-linked adenosine deaminase |
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