Development of the NADPH-diaphorase-positive neurons in the sympathetic ganglia |
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Authors: | Andrey I Emanuilov Marina B Korzina Liudmila I Archakova Svetlana A Novakovskaya Alexandr D Nozdrachev Petr M Masliukov |
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Institution: | aDepartment of Human Anatomy, Yaroslavl State Medical Academy, Yaroslavl, Russia;bDepartment of Normal Physiology and Biophysics, Yaroslavl State Medical Academy, Revoliucionnaya 5, Yaroslavl 150000, Russia;cInstitute of Physiology, NAS, Minsk, Belarus;dDepartment of Physiology, St. Petersburg State University, St. Petersburg, Russia |
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Abstract: | Changes in the distribution of NADPH-diaphorase (NADPH-d) were studied in neurons of the superior cervical ganglion (SCG), stellate ganglion (SG) and celiac ganglia (CG) in newborn, 10-, 20-day-old, 1-month-old, 2-month-old and 6-month-old rats, mice and kittens. NADPH-d-positive neurons were revealed in all sympathetic ganglia in kittens but not in rodents from birth onwards. In kittens, the largest population of NADPH-d-positive cells was found in the SG, the smallest in the SCG (<1%) and we observed only a few cells in the CG. The proportion of NADPH-d-positive cells in the SG increased from 3.1±0.15% in newborn kittens to 9.3±0.63% in 20-day-old animals and decreased further from 8.1±0.75% in 30-day-old kittens to 3.4±0.54% in 2-month-old animals. The content of NADPH-d-positive cells in the CG and SCG did not change during development. There were no differences in cross-sectional area between neurons located in different ganglia of animals from the same age group under study. We conclude that the development of NADPH-d-positive neurons in different sympathetic ganglia has its own time dynamics and is completed by the end of the second month of life. |
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Keywords: | Autonomic nervous system Sympathetic ganglia NADPH diaphorase Postnatal development |
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