| 复方尿囊素乳膏中尿囊素的含量测定 |
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| 引用本文： | 汤晟凌,兰海娟,邹慧龙.复方尿囊素乳膏中尿囊素的含量测定[J].中国药业,2008,17(1):22-23. |
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| 作者姓名： | 汤晟凌 兰海娟 邹慧龙 |
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| 作者单位： | 浙江省丽水市人民医院,浙江,丽水,323000 |
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| 摘 要： | 目的建立复方尿囊素乳膏中尿囊素的含量测定方法。方法采用高效液相色谱（HPLC）法，色谱柱为Zorbax NH2柱，流动相为甲醇-水（80：20），流速为1．0mL／min，检测波长为224nm。结果尿囊素质量浓度线性范围为187．68-938．40μg／mL，r=0．99995，平均回收率为99．90％，RSD=1．92％（n=9）。结论该方法专属性强，结果准确可靠，能很好地控制制剂质量。
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| 关 键 词： | 尿囊素 含量测定 高效液相色谱法 |
| 文章编号： | 1006-4931(2008)01-0022-02 |
| 修稿时间： | 2007年3月22日 |
Determination of Allantoin in Compound Allantoin Cream |
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| Tang Shengling,Lan Haijuan,Zou Huilong.Determination of Allantoin in Compound Allantoin Cream[J].China Pharmaceuticals,2008,17(1):22-23. |
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| Authors: | Tang Shengling Lan Haijuan Zou Huilong |
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| Institution: | (The People＇s Hospital of Lishui City, Lishui, Zhefiang, China 323000) |
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| Abstract: | Objective To establish a method for the determination of allantoin in Compound Allantoin Cream. Methods The content of allantoin was determined by HPLC. Zorbax- NH2 column was used with methanol：water =80：20 as the mobile phase. The flow rate was 1.0 mL/min,the detecting wavelength was at 224 nm. Results The linear range of allantoin was from 187.68 μg/mL to 938.40 μg/mL, r = 0. 999 95,and the average recovery rate was 99.90%, RSD = 1.92% （n =9）. Conclusion This method is special and accurate for the determination of allantoin. It can be used very well in the quality control of this cream. |
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| Keywords: | allantoin content determinatoin HPLC |
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