Monooxygenase activity of human epithelial cells (HeLa): Comparison of the response to treatment by arylhydrocarbons and diterpene esters期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Monooxygenase activity of human epithelial cells (HeLa): Comparison of the response to treatment by arylhydrocarbons and diterpene esters

Authors:	Walter G. Pyerin Erich Hecker

Affiliation:	(1) Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900 Heidelberg, Federal Republic of Germany;(2) Institut für Biochemie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900 Heidelberg, Federal Republic of Germany

Abstract:	Summary Arylhydrocarbons are inducers of monooxygenase activity in epithelial cells in culture (Hela) whereas diterpene esters are not. This is one more example of a specific biochemical difference — here in gene activation — exhibited by tumor initiators and tumor promoters of the classes of compounds assayed.Abbreviations TPA 12-O-tetradecanoylphorbol-13-acetate - 4-OMe-TPA 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate - P₂ 1-alkyldaphnane-type orthoester (Adolf et al. 1982) - 3-TI 3-tetradecanoyl-ingenol - DMBA 7,12-dimethylbenz(a)anthracene - BA benz(a)antracene - DMSO dimethylsulfoxide

Keywords:	Arylhydrocarbon monooxygenase Specific gene activation Human epithelial cells (HeLa) Arylhydrocarbons Diterpene esters
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