负重跑训练延缓大鼠骨骼肌衰变效果的研究

目的:研究负重跑训练延缓大鼠骨骼肌衰变的作用效果。方法:3月龄SD雄性大鼠36只,随机分为5组:6周安静组(n=6)、6周模型组(n=6)、12周模型组(n=8)、大负重组(n=8)和小负重组(n=8)。另外14月龄SD雄性大鼠8只作为自然衰老组。分别于第6周末和第12周末处死大鼠,测试各项指标。结果:与6周安静组相比,6周模型组大鼠血清超氧化物歧化酶(SOD)活力显著降低,血清丙二醛MDA和骨骼肌脂褐素含量均显著升高;12周模型组和自然衰老组在血清及骨骼肌的相关指标均出现了不同程度的衰变性表现,大、小负重两种训练方式均可以有效逆转以上的趋势,表现为显著提高血清SOD活力,以及SOD/MDA、骨骼肌总蛋白含量,降低血清MDA含量和骨骼肌脂褐素含量。结论:6周负重跑训练可以有效地延缓D-半乳糖大鼠骨骼肌衰变的进程。

The effect of loading run training on postponing skeletal muscle decay in rats

AbstractObjective: To study the effect of loading run training on postponing skeletal muscle decay in rats. Method: Thirty-six 3-month male SD rats were randomly assigned into five groups: 6-week control group(n=6), 6-week model group(n=6),12-week model group(n=8), large loading run training group(n=8) and little loading run training group(n=8). Eight 14-month male SD rats were taken as natural aging group. By the end of the 6th week and the 12th week, the rats were sacrificed. and the indicators were tested.Result: Comparing with 6-week control group, the activity of serum superoxide dismutase(SOD) in 6-week model group decreased, the content of serum malondiadehyde(MDA) and skeletal muscle lipofuscin increased. The indicators of serum and skeletal muscle in 12-week model group and natural aging group showed decay appearances on different levels. Large and little loading run training could reverse the changes effectively, increase the activity of serum SOD ratio of SOD/MDA and total protein level of skeletal muscle and decrease the content of serum MDA and lipofuscin of skeletal muscle. Conclusion: Six-week loading run weight training can postpone the skeletal muscle decay process of D-galactose rats effectively.