血清MMP-9、IL-6与急性冠脉综合征患者冠脉斑块稳定性的相关性

目的：探讨血清基质金属蛋白酶-9（MMP-9）及白细胞介素-6（IL-6）与急性冠脉综合征（ACS）患者冠状动脉斑块稳定性的相关性。方法：38例ACS患者作为观察组，行冠状动脉CT造影及冠脉造影检查；38例健康体检人员作为对照组，两组人员均接受血清MMP-9及IL-6检测，并在两组之间以及不同类型动脉粥样硬化斑块ACS患者中进行对比分析。结果：观察组血清MMP-9及IL-6水平明显高于对照组，差异具有统计学意义（P〈0．01）；且软斑块患者MMP-9及IL-6水平均明显高于混合斑块，差异具有统计学意义（P〈0．05）；而混合斑块患者又明显高于硬斑块（P〈0．05）；同时ACS患者血清MMP-9与IL-6水平呈正相关（r=0．724，P〈0．01）。结论：血清MMP-9及IL-6可作为斑块稳定性评估的重要指标，进而对ACS患者的早期干预治疗提供客观依据。

Correlation between Serum MMP-9, IL-6 levels and stability of coronary atherosclerotic plaques in patients with acute coronary syndrome

Objective： To discuss the correlation between serum MMP-9, IL-6 levels and stability of coronary atherosclerotic plaques in patients with acute coronary syndrome（ACS）. Methods： A total of 38 patients with ACS were selected as observation group, which underwent coronary CT tomography and coronary angiograph, 38 healthy volunteers were also enrolled as control group, MMP-9 and IL-6 levels in both groups were detected and compared between the two groups, and also between patients with diferent types of coronary atherosclerotic plaques in the observation group. Results： MMP-9 and IL 6 levels of the observation group were significantly higher in the observation group than that in the control group （P〈0.01）. Within the observation group, MMP-9 and IL-6 of patients with soft plaque were significantly higher than those with mixed plaques （P〈0.05）, and patients with mixed plaques showed significantly higher levels than those with hard plaques （P〈 0.05） ,there was a significant positive correlation between serum MMP-9 and IL-6 level in patients with ACS. Conclusion： Serum MMP-9 and IL-6 can be used as important indicators to assess the stability of coronary atherosclerotic plaques in patients with ACS, and provide an objective basis for early intervention treatment of ACS.