WWOX 抑癌基因研究进展

WWOX 基因定位于染色体16q23.3-24.1,在卵巢癌、乳腺癌、肝细胞癌、前列腺癌及其他肿瘤中检测到其杂合性缺失及染色体重排.该基因位于染色体普通脆性位点16D, 包含9个外显子,编码414个氨基酸相对分子量为46 000大小的蛋白.原发肿瘤组织及细胞系的研究证明该基因为肿瘤抑制基因,其失活可能导致肿瘤的发生,基因敲除实验证实了上述假设.WWOX可能和c-Jun, TNF, p53, p73, AP-2γ,及E2F-1等相互作用而发挥凋亡作用.目前对于该基因是否为肿瘤抑制基因仍存在不同观点,随着研究结果的积累,WWOX基因的功能会日渐明了,并对肿瘤的诊断、治疗和预防产生积极的影响.

Update of the WWOX tumor suppressor gene

The WWOX gene,which is located at 16q23.3-24.1.,Its deletion of heterozygosis and chromosomal rearrangements has been detected in ovarian,breast,hepatocellular,and prostate carcinomas and in other neoplasias.This gene,which spans the common chromosomal fragile site 16D,contains 9 exons and encodes a 46 000 WWOX protein that contains 414 amino acids.The evidence from cancer cell lines and primary tumor tissues suggests that WWOX is a tumor suppressor gene and that its inactivation contributes to cancer development.The results from studies of WWOX gene knockout cancer cells and a WWOX knockout mouse model partly confirm this hypothesis.The WWOX protein can interact with c-Jun,TNF,p53,p73,AP-2gamma and E2F-1,and plays a central role in tumor apoptosis.However,it is still controversial whether WWOX is a tumor suppressor gene.As the researches carry on,the function of WWOX will be unveiled,and the gene may play an active role in prevention,diagnosis and the treatment of tumor.