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Association between asthma and an intragenic variant of CC16 on chromosome 11q13 |
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| Authors: | X-Q Mao T. Shirakawa M. Kawai T. Enomoto S. Sasaki Y. Dake H. Kitano A. Hagihara JM Hopkin K. Morimoto |
| Affiliation: | Department of Hygiene and Preventive Medicine, Osaka University School of Medicine, Suita, Japan,;Osler Chest Unit, Churchill Hospital, Oxford, UK,;Kyoto Preventive Medical Centre, Kyoto,;Department of ORL, Japanese Red Cross Society, Wakayama Medical Centre, Wakayama,;Department of Pediatrics, Osaka College of Medicine, Takatsuki,;Department of ORL, Shiga University of Medical Science, Ohtsu,;Department of Health Services Management and Policy Kyushu University Graduate School of Medicine, Fukoka, Japan |
| Abstract: | The β subunit of high affinity immunoglobulin E (IgE) receptor (FcɛRIβ) and the Clara cell derived inflammatory molecule, CC16 have been cited as candidate genes for atopic asthma on chromosome 11q13. A genetic association study was performed with an intragenic microsatellite repeat of CC16 gene on chromosome 11q12–13 in relation to atopic and non-atopic asthma. Whereas variants of FcɛRIβ at chromosome 11q13 show association with atopy and asthma, no significant association was found between asthma and CC16 genotypes irrespective of atopic status. These data support the candidacy of FcɛRIβ rather than CC16 for the atopic asthma locus on chromosome 11q. |
| Keywords: | association study asthma CC16 polymorphism |