|
|||||
|
|
| 用高效液相色谱法测定萘普生片和萘普生钠片的生物利用度 | |
| 引用本文： | 李端,刘德林,朱明,杨香媛,施辛,李征. 用高效液相色谱法测定萘普生片和萘普生钠片的生物利用度[J]. 复旦学报(医学版), 1990, 0(3) |
| 作者姓名： | 李端 刘德林 朱明 杨香媛 施辛 李征 |
| 作者单位： | 上海医科大学药学院药理学教研室(李端，朱明，杨香媛)，上海医科大学药学院仪器分析中心室(刘德林)，上海黄河制药厂(施辛)，上海黄河制药厂(李征) |
| 摘 要： | 用改进的高效液相色谱法测定萘普生的血浆浓发。在8名男性受试者,按交叉设计口服同等克分子量的萘普生片(500mg)和萘普生钠片(550mg)后,经对表明生物利用度的三个主要药代动力学参数作自身对照的统计学处理,证明萘普生钠片口服吸收显著地较萘普生片快(T_(max),P<0.05),峰浓度也高(C_(max),P<0.05),但吸收程度不变(AUC_(0～24h),P>0.05)。提示,作为镇痛剂,萘普生钠看来是萘普生的一种改进形式。 |
| 关 键 词： | 萘普生 萘普生钠 生物利用度 药代动力学 高效液相色谱法 |
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THE B1OAVAILABILITY OF NAPROXEN WHEN GIVEN ORALLY IN TABLET FORM OR AS NAPROXEN SODIUM TABLETS |
|
| Li. Duan,Liu Delin,Zhu Ming,Yang Xiangyuan,Shi Xin,Li Zheng. HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC DETERMINATION OF THE B1OAVAILABILITY OF NAPROXEN WHEN GIVEN ORALLY IN TABLET FORM OR AS NAPROXEN SODIUM TABLETS[J]. Fudan University Journal of Medical Sciences, 1990, 0(3) | |
| Authors: | Li. Duan Liu Delin Zhu Ming Yang Xiangyuan Shi Xin Li Zheng |
| Abstract: | Plasma concentrations of naproxen were determinated by an improved method ufiing high-performance liquid ohromatpgraphy. Comparative bioa variability studies after administration of 500 mg tablets of naproxen orally and equi molar 550 mg tablets of naproxen sodium were conducted on 8 adult male volunteers using a crossover design. Statistical analyses of the pharmacokinetic parameters (including Tmax, Omax and AUC0-24h) showed that the volunteers achieved significantly earlier and higher plasma leyels of naproxen when naproxen sodium waf administered (Tmax, P<0.05, Cmax, P<0.05). However, the total absorption of naproxen and naproxen sodium, as indicated by the areas under the curve, was equal. This suggests that naproxen, sodium appears to be a more advantageous, form of naproxen for use as an analgesic agent. |
| Keywords: | naproxen naproxen sodium bioavallability pharhiacokine-tics high-performance liquid chrornatography |
| 本文献已被 CNKI 等数据库收录！ | |