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| MUC1、MUC3在结石性胆囊炎和胆囊腺瘤样息肉粘膜组织中的表达及其意义 | |
| 引用本文： | 曹红,陈东风,郑伟. MUC1、MUC3在结石性胆囊炎和胆囊腺瘤样息肉粘膜组织中的表达及其意义[J]. 中国普外基础与临床杂志, 2003, 10(4): 379-382 |
| 作者姓名： | 曹红 陈东风 郑伟 |
| 作者单位： | 1. 第三军医大学大坪医院野战外科研究所肝胆外科,重庆,400042 2. 第三军医大学大坪医院野战外科研究所消化内科 |
| 摘 要： | 目的 探讨粘蛋白 (MUC1,MUC3 )在结石性胆囊炎和胆囊腺瘤样息肉中的表达规律。方法 采用免疫组化AEC法和蛋白印迹杂交 (Westernblot)方法对 2 0例正常胆囊标本 (对照组 ) ,3 8例结石性胆囊炎 (结石组 )及 18例胆囊腺瘤样息肉 (息肉组 )的胆囊粘膜中MUC1、MUC3的表达进行检测。结果 免疫组化检测与蛋白印迹杂交分析结果均显示 ,结石组及息肉组MUC1的表达阳性率明显高于对照组 (P<0 .0 1) ,而MUC3的表达阳性率则明显低于对照组(P<0 .0 1) ;结石组MUC3的表达阳性率又明显高于息肉组 (P<0 .0 1)。结论 MUC1和MUC3在结石性胆囊炎及胆囊腺瘤样息肉中的表达呈负相关 ,这可能与结石形成及胆囊癌前病变有关。 |
| 关 键 词： | MUC1 MUC3 结石性胆囊炎 胆囊腺瘤 腺瘤样息肉 粘膜组织 基因表达 |
| 文章编号： | 1007-9424(2003)04-0379-04 |
| 修稿时间： | 2002-10-28 |
Value of MUC1 and MUC3 in the Calcareous Cholocystitis and Cholecystic Adenomatoid Polyps |
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| CAO Hong ,CHEN Dong-feng,ZHENG Wei. Depantment of Hepatobiliary Surgery and Gastroenterology,Daping Hospital,The Third Military Medical University,Chongqing ,China. Value of MUC1 and MUC3 in the Calcareous Cholocystitis and Cholecystic Adenomatoid Polyps[J]. Chinese Journal of Bases and Clinics In General Surgery, 2003, 10(4): 379-382 | |
| Authors: | CAO Hong CHEN Dong-feng ZHENG Wei. Depantment of Hepatobiliary Surgery Gastroenterology Daping Hospital The Third Military Medical University Chongqing China |
| Affiliation: | CAO Hong *,CHEN Dong-feng,ZHENG Wei. *Depantment of Hepatobiliary Surgery and Gastroenterology,Daping Hospital,The Third Military Medical University,Chongqing 400042,China |
| Abstract: | Objective To study the change of mucins of expression in lithic cholecystitis and cholecystic adenomatiod polyps. Methods MUC1 and MUC3 were detected in the mucosa of human normal gallbladders (20 cases, control group), of calcareous cholecystitis (38 cases, calcareous group) and of adenomatoid polyps (18 cases, polyp group) with immunohistochemical stains and Western blotting methods. Results The positive rate and optical density values of MUC1 were increased significantly in calcareous and polyp group vs control group ( P <0.01), otherwise, MUC3 was decreased markedly ( P <0.01). Conclusion The expressions of MUC1, MUC3 were not synchronization in different lesions of cholecyst. |
| Keywords: | Mucin Cholecystitis Adenomatoid polyp |
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