| 棘霉素诱导肝癌SMMC7721细胞凋亡的研究 |
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| 引用本文： | 徐静,陈孝平. 棘霉素诱导肝癌SMMC7721细胞凋亡的研究[J]. 山东医药, 2007, 47(15): 14-16 |
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| 作者姓名： | 徐静 陈孝平 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院,湖北武汉,430030;广西医科大学第一附属医院
2. 华中科技大学同济医学院附属同济医院,湖北武汉,430030 |
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| 基金项目： | 广西壮族自治区科技计划 |
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| 摘 要： | 目的研究棘霉素诱导肝癌SMMC7721细胞凋亡的作用,探讨其抗肿瘤的作用机制。方法通过细胞计数获得不同浓度棘霉素作用SMMC7721细胞的生长抑制率,观察棘酶素对肝癌细胞生长的影响;通过流式细胞仪分析棘霉素对细胞凋亡和细胞周期的影响。结果棘霉素浓度〉10 ng/ml时可抑制SMMC7721细胞的生长。结论棘霉素在体外可诱导肝癌细胞凋亡,具有很强的抗肿瘤作用。
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| 关 键 词： | 棘霉素 肝肿瘤 细胞凋亡 |
| 文章编号： | 1002-266X（2007）15-0014-03 |
| 修稿时间： | 2007-02-28 |
Study on echinomycin inducing cell apoptosis in SMMC7721 cells |
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| XU Jing,CHEN Xiao-ping. Study on echinomycin inducing cell apoptosis in SMMC7721 cells[J]. Shandong Medical Journal, 2007, 47(15): 14-16 |
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| Authors: | XU Jing CHEN Xiao-ping |
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| Affiliation: | 1 Tongji Hospital ,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030 ,P. R. China |
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| Abstract: | [Objective] To investigate the apoptosis of of human hepatocellular carcinoma cell line SMMC7721 cells induced by echinomycin and its mechanism.[Methods] SMMC7721 cells were treated with different concentrations of echinomycin,cell viability was detected by cell amounts.cell apoptosis and cell cycles were observed by flow cytometry(FCM).[Results] Cell proliferation was inhibited when treated with 10 ng/ml or higher concentration of echinomycin.[Conclusion] Echinomycin has very strong antitumor effect in vitro and the mechanism may be associated with the effect of inducing cell apoptosis. |
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| Keywords: | echinomycin liver neoplasms apoptosis |
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