三苯氧胺对子宫内膜的影响

目的：观察乳腺癌患者服用三苯氧胺（TAM）后对子宫内膜的影响。方法：26例乳腺癌患者服用TAM（TAM组）后出现阴道异常出血或B超检查发现子宫内膜增厚而行宫腔镜检查及子宫内膜病理检查。另外以同时期无TAM服药史的非乳腺癌患者因绝经后阴道出血而行宫腔镜检查的78例作为对照组。结果：TAM组发生子宫内膜息肉和宫颈息肉共13例（50.0%），而对照组为14例（17.9%)，两组比较，差异有显著性（P＜0.05)。TAM组发生子宫内膜增生9例（34.6%)，明显高于对照组的12例（15.4%,P＜0.05)。结论：乳腺癌患者长期服用TAM后子宫内膜病变增多，故对这些患者应进行B超监测子宫腔镜检查。

The effect of tamoxifen of endometrium

Objective To evaluate the effect of tamoxifen on the endometrium Methods Hysteroscopy and endometrial biopsies were performed in 26 patients with breast cancer receiving tamoxifen and having vaginal bleeding or endometrial thickness detected by ultrasound In addition 78 women with postmenopausal bleeding without receiving tamoxifen underwent the same examination Results Thirteen (50 0%) patients receiving tamoxifen had endometrial or endocervical polyps, whereas 14 cases(17 9%) not receiving tamoxifen developed the polyps ( P <0 05) Nine (34 6%) patients receiving tamoxifen had thyperplasias, which was significantly higher than that of women not receiving tamoxifen ( P <0 05) Conclusions The incidence of endometria disease in the patient with breast cancer receiving tamoxifen was increased These patients should be closely monitored by transvaginal sonography and hysteroscopy