活动期类风湿关节炎中医证候分布研究

目的:初步探讨活动期类风湿关节炎(RA)的中医证候分布特征。方法:采用SPSS(13.0),选择活动期RA患者126例,研究中医证候与病程,类风湿因子(RF)、C反应蛋白(CRP)、血沉(ESR)等实验室指标及晨僵等主要临床症状、体征,X线征象分期之间的相关性。结果:活动期RA患者证候分布比例差异较大,不同证候在病程、双手X线分期上存在差异。活动期RA中医证候在主要临床症状、体征与相关实验室指标上差异无显著性(P>0.05)。结论:"邪从热化"趋势是活动期RA病机的主要标本特征。反映出随着RA疾病不断进展,其病机变化存在着一个由实至虚实夹杂,再到虚的动态演变规律。关节疼痛数等主要临床症状、体征及ESR等实验室指标并不能反映活动期RA中医证候分布上的变化。

Distribution research of TCM syndrome on rheumatoid arthritis

Objective：To explore the characteristics of TCM syndrome distribution on rheumatoid arthritis （RA）. Methods： 126 patients were selected for correlation research of TCM syndrome with course of the disease, rheumatoid factor （RF）, c-reactive protein （CRP）, blood sedimentation （ESR） and morning stiffness, the main clinical symptoms, physical signs, X-ray signs. Results：The difference is obviously different in the course of the disease, hands on X-ray stage. Conclusion：The trend of Xiecong Rehua is a main feature of RA pathogenesis during active stage. As long as a continuous development of RA, pathogenesis change always come with a dynamic evolution from Shi to Xu/Shi finally to Xu. Clinical symptoms of joint pain, body signs and laboratory parameters such as ESR does not reflect the TCM syndromes distribution of active RA.