Exacerbation of Secondary Pulmonary Hypertension by Flat Chest after Lung Transplantation |
| |
| Authors: | Haruhiko Shiiya Masaaki Sato Aya Shinozaki-Ushiku Chihiro Konoeda Kentaro Kitano Jun Nakajima |
| |
| Affiliation: | 1.Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan;2.Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan;3.Department of Pathology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan |
| |
| Abstract: | ![]()
A 40-year-old woman with idiopathic pleuroparenchymal fibroelastosis (IPPFE) and flat chest underwent left single lung transplantation (SLT). Although she had developed over-systemic pulmonary arterial pressure (PAP) at transplantation, it was alleviated. However, her PAP gradually increased again. Her transplanted lung was well-inflated, but progression of fibrosis in her right native lung appeared to have caused a mediastinal shift, and her flat chest caused obstruction of the outflow tract of the pulmonary vein. She died of heart failure and associated infection 1.5 years after transplantation. An autopsy confirmed irreversible pulmonary arterial and venous changes in the transplanted lung, suggestive of chronic pressure overload. The flat chest associated with IPPFE can affect pulmonary circulation after SLT. |
| |
| Keywords: | chest wall pulmonary arteries/veins pulmonary vascular resistance/hypertension interstitial lung disease transplantation lung |
|
|
