A cocaine analog and a GBR analog label the same protein in rat striatal membranes. |
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| Authors: | A Patel J W Boja J Lever R Lew R Simantov F I Carroll A H Lewin A Philip Y Gao M J Kuhar |
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| Affiliation: | Neuroscience Branch, Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224. |
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| Abstract: | Because some evidence suggests that cocaine and GBR12935 bind to different sites, we utilized photoaffinity probes from both classes of compounds to see if they label the same protein. [125I]RTI-82 a cocaine analog, and [125I]DEEP, a GBR analog, labeled protein(s) showing the same molecular weight, a similar pharmacological profile and a similar sensitivity to neuraminidase. |
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