Improvement of Cardiac Contractile Function in Rats with Postinfarction Cardiosclerosis after Transplantation of Mononuclear and Multipotent Stroma Bone Marrow Cells |
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| Authors: | O. N. Khokhlova I. A. Ilyushkina T. Kh. Fatkhudinov G. A. Slashcheva Yu. P. Baikova G. B. Bol’shakova T. B. Bukharova V. I. Turobov V. V. Glinkina A. N. Murashev D. V. Gol’dshtein |
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| Affiliation: | Laboratory of Biological Testing, Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino; ReMeTeks Company; Laboratory of Growth and Development, Research Institute of Human Morphology, Russian Academy of Medical Sciences; Laboratory of Stem Cell Genetics, Medical Genetic Research Center, Russian Academy of Medical Sciences; Department of Histology and Embryology, N. I. Pirogov National Research Medical University, Ministry of Health and Social Development of the Russian Federation, Russia. khohlova@fibkh.serpukhov.su. |
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| Abstract: | ![]()
We compared the efficiency of autologous mononuclear cells and multipotent stromal cells of the bone marrow after their non-selective intracoronary transplantation on day 30 after acute coronary infarction in rats. Improvement of hemodynamic parameters of myocardial contractility (rates of left ventricular pressure rise and drop) in comparison with the initial values and deceleration of postinfarction prolongation of QRS and QT intervals were observed in rats of the experimental group in contrast to controls in 4 weeks after transplantation. These functional changes were more intensive after transplantation of multipotent stromal cells and were accompanied by more pronounced morphological signs of reverse myocardial remodeling: thickening of the scarred left ventricular wall, shrinkage of the scar, and decrease in left ventricular dilatation index. |
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