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| 80株结核分枝杆菌临床分离株耐药性特点 | |
| 引用本文： | 王超,朱中元,曾涛,王海波. 80株结核分枝杆菌临床分离株耐药性特点[J]. 中国热带医学, 2009, 9(11): 2141-2142 |
| 作者姓名： | 王超 朱中元 曾涛 王海波 |
| 作者单位： | 1. 海南大学环境与植物保护学院,海南,儋州,571737;海南省农垦总局医院检验科,海南,海口,570311 2. 海南省农垦总局医院检验科,海南,海口,570311 3. 海南大学环境与植物保护学院,海南,儋州,571737 |
| 基金项目： | 海南省卫生厅科技发展基金项目 |
| 摘 要： | 目的 分析结核分枝杆菌临床分离株对5种抗结核药物的药物敏感性。方法用改良罗氏培养法测定结核分枝杆菌临床分离株的耐药性（MIC）、耐药率。结果80株结核分枝杆菌临床分离株对INH、RFP、EMB、SM和LVFX的平均MIC分别为9．7μg／mL、30．1μg／mL、16．4μg／mL、38．7μg／mL和0．9μg／mL；耐药率分别是67．2％、35．0％、53．8％、63．8％和16．3％。总耐药率为83．75％；耐单药率为17．5％；耐多药率为66.3％；耐多药株占总耐药株的79．1％。结论80株结核分枝杆菌临床分离株耐药率和耐多药率都较高，结核病的防治将面临更大的困难。 |
| 关 键 词： | 结核病 结核分枝杆菌 药物敏感性试验 耐药性 |
Drug resistance of 80 clinical isolates of Mycobacterium tuberculosis |
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| Affiliation: | WANG Chao,ZHU Zhong-yuan,ZENG Tao,et al. (College of Environment and Plant Protection, Hainan University, Danzhou 571737, Hainan, P. R. China) |
| Abstract: | Objective To analyse drug susceptibility of clinical isolates of Mycobacterium tuberculosis （MTB）. to 5 anti-tuberculosis drugs. Methods The MICs were determined using Lowenstein-Jensen medium,and the drug resistantance rates were calculated. Results Average MICs of 80 clinical MTB isolates against INH,RFP,EMB,SM and LVFX were 9.7 g/mL,0.1g/mL,16.4 g/m,38.7 g/mL and 0.9 g/mL respectively .The resistantance rate to the drugs were 67.16% ,35.0% ,53.8% ,63.8% and 16.3% respectively. The total resistantance rate,single-drug resistantance rate and multiple drug resistantance rate were 83.75%, 17.5% ,and 79.1% respectively. Multiple drug resistantance strains accounted for 16.7% of all the resistantance strains. Conclusion The drug resistantance rate and multiple drug resistantance rates are both very high. |
| Keywords: | Tuberculosis （TB） Mycobacterium tuberculosis（MTB） Drug susceptibility test Drug resistantance |
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