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Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer''s disease
Authors:M.E De Leo  S Borrello  M Passantino  B Palazzotti  A Mordente  A Daniele  V Filippini  T Galeotti  C Masullo
Affiliation:

a Institute of General Pathology, Catholic University, School of Medicine, Largo F. Vito, 1-00168 Rome, Italy

b Institute of Biological Chemistry, Catholic University, School of Medicine, Largo F. Vito, 1-00168 Rome, Italy

c Institute of Neurology, Catholic University, School of Medicine, Largo F. Vito, 1-00168 Rome, Italy

Abstract:
Substantial evidence supports the hypothesis that oxygen free radicals are involved in various neurodegenerative disorders. To assess the presence of oxidative stress in Alzheimer's disease (AD) we examined the activity of the enzyme copper-zinc superoxide dismutase (CuZnSOD) in red blood cells, the levels of the mitochondrial inducible enzyme manganese superoxide dismutase (MnSOD) mRNA in lymphocytes, and the total radical-trapping antioxidant capacity (TRAP) in plasma of AD patients and in a group of age-matched non-demented controls. We found that CuZnSOD activity (P<0.01 vs. controls) was significantly increased as well as the MnSOD mRNA levels while the total antioxidant status (P<0.001 vs. controls) was decreased in AD patients. These findings support the role of oxidative alterations in the pathogenetic mechanism underlying AD neurodegeneration.
Keywords:Alzheimer's disease   Oxidative stress   Manganese superoxide dismutase mRNA
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