含左氧氟沙星方案治疗耐多药肺结核疗效分析

目的:评价左氧氟沙星(LVFX)对耐多药肺结核(MDR PTB)的疗效.方法:122例MDR PTB随机分为两组,治疗组用LVFX＋3HThEK(C)/6HThE方案治疗,对照组用3HThEPK(C)/6HThEP方案治疗.结果:疗程结束时治疗组痰菌阴转率和病灶吸收率分别为88.5%,80.3%,明显高于对照组63.9%,59.0%(P＜0.05);治疗组病灶显著吸收率、空洞缩小率和症状好转率均优于对照组.结论:左氧氟沙星是氟喹诺酮类中治疗耐多药肺结核的有效药物.

Therapeutic Effect of Levofloxacin on Multidrug Resistant Pul monary Tuberculosis

Objective:To evaluate the therapeutic effect of levofloxacin (LVFX) on multidrug resistant pulmonary tuberculosis (MDR PTB). Methods:122 cases of MDR PTB were allocated at random to two groups. Chemotherapy regimen: the therapy group were treated with LVFX+3HThEK(C)/6HThE; the control group were treated with 3HThEPK(C)/6HThEP. Results:When chemotherapy was over, the sputum negative conversion rates and focal absorption rates of the therapy group were 88.5% and 80.3%, while the rates of the control group were 63.9% and 59.0% ( P <0.05). The effective focal absorption rates, cavity vanishing rates and symptom improving rates were all higher than those of the control group. Conclusion:Levofloxacin is an effective drug in treating patients with MDR PTB among quinolones.