An approximate estimate of the ion-activity product of calcium oxalate in rat urine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

An approximate estimate of the ion-activity product of calcium oxalate in rat urine

Authors:	Hans-G?ran?Tiselius mailto:hans.tiselius@hs.se" title=" hans.tiselius@hs.se" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Renato?Ribeiro Nogueira Ferraz,Ita?Pfeferman Heilberg

Affiliation:	(1) Department of Urology, Center for Surgical Sciences, Karolinska Institutet, Huddinge University Hospital, 141 86 Stockholm , Sweden;(2) Department of Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil

Abstract:	The objective of this report was to derive a simplified approximate estimate of the ion-activity product of calcium oxalate (AP_CaOx) in rat urine. The relative effect of each urine variable was assessed by means of iterative computerised approximation with the EQUIL2 program. A basic urine composition was chosen from literature and experimental data. The most pronounced influence on AP_CaOxwas recorded for urinary calcium, oxalate, citrate, magnesium and volume. Based on these calculations, an AP(CaOx) index_RAT was formulated: $frac{{A cdot Calcium^{{0.93}} cdot Oxalate^{{0.96}} }} {{(Citrate + F)^{{0.60}} cdot Magnesium^{{0.55}} cdot Volume^{{0.99}} }}$ . For a 24-h urine sample, factor A takes the value 4067 and factor F should be set to 0.015. Conclusion. A simplified approximate estimate of AP_CaOx was derived for rat urine. There was a reasonably good correspondence between AP(CaOx) index_RAT and AP_CaOx, as derived from EQUIL2 (r=0.890), provided the other urine variables do not deviate very much from that in the basic composition.

Keywords:	Calcium oxalate Rat Urine Ion-activity product
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