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| 两种抗肿瘤药物影响生物陶瓷人工骨与骨结合的研究 | |
| 引用本文： | 王慧明 王模堂 王翰章. 两种抗肿瘤药物影响生物陶瓷人工骨与骨结合的研究[J]. 口腔材料器械杂志, 1994, 3(2): 65-67 |
| 作者姓名： | 王慧明 王模堂 王翰章 |
| 作者单位： | 浙江医科大学附属一院(王慧明!310003)，华西医科大学口腔医学院(王模堂，王翰章) |
| 摘 要： | 为了探讨抗肿瘤药平阳霉素(BLM)及氨甲喋呤(MTX)对生物陶瓷人工骨与骨结合的作用,作者以杂种狗为种植模型,采用定量组织测量学、生物力学、元素分析的定量分析方法考察了骨与人工骨的结合区.结果发现在植入后1.5月MTX不仅能抑制局部新骨的生长与钙化,而且能减少骨与人工骨的结合,从而降低了人工骨植入体的稳定性.而同期BLM上述作用却不明显,因此作者认为对于肿瘤术后人工骨修复的患者的术后化疗拟应用BLM为宜. |
| 关 键 词： | 生物陶瓷 骨结合 化疗 |
Qantitative Study on Antineoplastic Agents Affect Osteogensis and Bone Bonding at Interface Between Bioceramic and Bone |
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| Wang HuimingThe st Affiliated Hospital of Zhejiang Medical U-niversity Wang Moutang,Wang Hanshang College of Stomatology,West China University of Medical Sci-. Qantitative Study on Antineoplastic Agents Affect Osteogensis and Bone Bonding at Interface Between Bioceramic and Bone[J]. Chinese Journal of Dental Materials and Devices, 1994, 3(2): 65-67 | |
| Authors: | Wang HuimingThe st Affiliated Hospital of Zhejiang Medical U-niversity Wang Moutang Wang Hanshang College of Stomatology West China University of Medical Sci- |
| Affiliation: | Wang HuimingThe 1st Affiliated Hospital of Zhejiang Medical U-niversity Wang Moutang,Wang Hanshang College of Stomatology,West China University of Medical Sci- |
| Abstract: | In this experiment, the author used the method of Histometry, biomechanic test and EDXA to evaluate osteogenesis and bone bonding at bioceramic implant/bone interface affected by Bleomycine ( BLM ) and Methotrexate ( MTX ).The results showed that in MTX group there exist reduction in bone volume, bonding area and Ca/P of new bone as well as bonding stress by contrast with those in control group at 1. 5 months. But there was no significant statistic differences between BLM and control group. This study indicated MTX is able to delay the new bone formation and bonding. Tt is valuble for e-hecting antineoplastic agents for postoperative cnemotherapy after the jaw bone bioceramic replacement. |
| Keywords: | bioceramic osteogensis chemotherapy. |
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