| 癌基因C-erbB-2在胃癌组织的表达及临床意义 |
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| 引用本文： | 宫立群,尹浩然,朱正纲,林言箴,王瑞年.癌基因C-erbB-2在胃癌组织的表达及临床意义[J].外科理论与实践,1996(Z1). |
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| 作者姓名： | 宫立群 尹浩然 朱正纲 林言箴 王瑞年 |
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| 作者单位： | 天津市肿瘤医院 300060(宫立群)，上海第二医科大学瑞金医院外科 200025(尹浩然，朱正纲，林言箴)，上海第二医科大学病理学教研室 200025(王瑞年) |
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| 基金项目： | 上海市高教局重点学科基金资助项目 |
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| 摘 要： | 用兔抗人C-erbB-2抗体对133例人胃癌组织进行了免疫组织化学研究,其中24例呈阳性反应(18.1%).结果显示:C-erbB-2表达阳性者有较好的生物学特性.C-erbB-2基因的过度表达是胃癌恶性程度较低的一个指标,术前组织活检测定C-erbB-2的表达情况,有助于判断胃癌的恶性程度,制订手术切除和淋巴结清扫范围.对86例胃癌患者进行了术后5年随访,统计后发现C-erbB—2阳性的病例比阴性病例有较低的近期死亡率和较高的5年生存率,但无显著性差异(P>0.05).C-erbB-2表达与胃癌预后的关系,有待于在更大的病组中作进一步研究.
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| 关 键 词： | 胃癌 免疫组织化学 C-erbB-2基因 |
Expression and Clinical Implication of C-erbB-2 Genein Gastric Cancer |
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| Gong Liqun,et al..Expression and Clinical Implication of C-erbB-2 Genein Gastric Cancer[J].Journal of Surgery Concepts & Practice,1996(Z1). |
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| Authors: | Gong Liqun |
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| Abstract: | By using an antibody specific for C-erbB-2 oncogene an im-munohistochemical study of the expression of C-erbB-2 was performed in 133 human gastric cancer specimens. Expression of the protein was detected in 24 cases (18.1%). The results suggested that C-erbB-2 positive cases had better biological behaviors. Preoperative determination of the C-erbB-2 level in biopsy specimens might be useful to estimate the malignant potential of the tumor involved and in planning the treatment for the patient. Follow-up study of 86 gastric patients showed that C-erbB -2 positive cases presented a lower mortality and a higher survival rate than those of C-erbB-2 negative cases, but the difference was not statistically significant (P>0.05). Studies on larger series of patients will be needed for the ultimate verification of the prognostic value of C-erbB-2. |
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| Keywords: | gastric cancer Immunohistochemistry C-erbB-2 gene prognosis |
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