结缔组织病患者的肺功能表现

目的探讨结缔组织病患者肺功能受损的情况及其病理生理原因。方法测定80例患者的肺功能，并与正常对照组进行比较。结果弥散功能显著减低，且有显著性差异(P＜0.05)；异常百分率经综合分析自高至低依次为弥散功能为68.7%，小气道阻塞为46.0%，肺气肿为42.0%，通气功能减退为28.7%，阻塞性通气障碍为26.2%，限制性通气障碍为21.2%；相关分析显示一氧化碳弥散量与肺总量呈正相关(r=0.68，P＜0.01)。结论结缔组织病患者的肺功能损害以弥散功能减退为主，其次可见小气道阻塞、肺气肿、通气功能减退，其肺功能损害的病理生理基础是肺间质受累致肺毛细血管床减少、间质纤维化、小气道阻塞及肺容积的改变。

The features of pulmonary function in patients suffering from connective tissue disease

Objective To explore the pathophysiological reasons for pulmonary function disturbance in patients suffering form connective tissue disease(CTD).Methods General pulmonary function of 80 CTD patients was measured and the data were compared with that of the control group.Results Test showed that the diffusing capacity was reduced remarkably with significant difference(P<0.05).68.7% of the patients had abnormal diffusing capacity;the incidence of small airway obstruction was 46%;emphysema changes were seen in 42% of the patients;28.7% of the patients showed decrease of ventilatory function;26.2% showed obstructive ventilitory disorder and 21.2% showed restrictive ventilitory disorder.Relevant analysis indicated that (DLco) and (TLC) were positively related (r=0.68, P<0.01) .Conclusion The most chracteristic pulmonary function change in CTD is the decrement of diffusing capacity.In addition,small airway obstruction,emphysema and the decrement of ventilitory capacity can also be found.The pathophysiological mechanism for pulmonary function disturbance exists in the blood capillary bed decrease,interstitial fibrosis,small airway obstruction and lung capacity changes.