原发性高血压患者脉搏波传导速度与靶器官损害的相关性研究

目的探讨原发性高血压患者肱踝脉搏波传导速度（baPWV）与靶器官损害的关系。方法对所有患者行心电图、超声心动图、颈动脉超声和baPWV检测,并查尿微量蛋白。根据baPWV测量结果,将106例原发性高血压患者分为baPWV〉1400cm／s组（A组）61例,baPWV≤1400cm／s组（B组）45例。结果baPWV〉1400cm／s组靶器官损害发生率高于baPWV≤1400cm／s组（P〈0．05）;颈动脉内膜厚度（CIMT）、颈动脉斑块评分（Crouse-s）、尿微量蛋白（mAlb）、左心室重量指数（LVMI）较baPWV≤1400cm／s组明显增高（P〈0．05）;直线相关分析示baPWV与CIMT、LVMI成正相关（P〈0．05）。结论高血压患者心脑血管事件发生率明显增加与动脉弹性降低有关;靶器官损害与增加的baPWV密切相关。

Relationship between artery pulse wave velocity and target organs damage in patients with essential hypertension

Objective To investigate the relationship between brachial - ankle artery pulse wave velocity and target organs damage in patients with essential hypertension. Methods Electrocardiography, echocardiography, carotid ultrasonography, brachial - ankle artery pulse wave velocity, microalbum inuria were measured in all patients. 106 essential hypertensive patients were divided into two groups according to the levels of baPWV ： baPWV 〉 1400cm/s group （ group A, n = 61 ） ; baPWV ≤ 1400cm/s group （ group B, n = 45）. Results Compared with subjects in group A and group B, group A showed higher the incidence rate of target organs damage （P 〈 0. 05 ） and higher levels of left ventricular mass index （LVMI）, carotid intimamedial thickness （CIMT）, carotid plaque score （Crouse -s） and microalbum inuria （mAlb） than that in group B （P 〈0.05）. In linear correlation analysis, baPWV was positive correlation with CIMT, mAlb and LVMI （P 〈 0. 05）. Conclusion The higher incidence rate of heart, brain and blood vessel events are related with artery elasticity decreasing; Target organs damage is close correlation with baPWV increaseing in patients with essential hypertension.