E-钙粘附素的表达与胃癌临床病理特征的关系

目的：探讨 Ｅ钙粘附素（ Ｅ Ｃ Ｄ） 表达与胃癌生物学行为的关系。方法：采用免疫组化染色方法检测８０ 例胃癌组织 Ｅ Ｃ Ｄ 的表达情况。结果：正常胃粘膜呈 Ｅ Ｃ Ｄ 保留表达，８６３ ％ （６９／８０） 的胃癌 Ｅ Ｃ Ｄ 表达减弱或消失； Ｅ Ｃ Ｄ 表达减弱与胃癌浸润型生长及分化较差密切相关（ Ｐ＜ ００１） ，而与胃癌浸润深度、淋巴结转移、静脉、淋巴管润浸无关（ Ｐ＞ ００５） 。结论： Ｅ Ｃ Ｄ 的表达可能决定着胃癌的生长方式和分化程度，而与胃癌侵袭转移潜能无关。

Immunohistochemical study of the expression of E cadherin in human gastric cancer

Objective:To evaluate the correlation between the expression of E cadherin(E CD) and the biological behaviors of gastric cancer.Methods:The expression of E CD was detected immunohistochemically in 80 resected gastric carcinoma specimens.Results:The E CD expression was well preserved in normal gastric mucosa,whereas 86 3%(69/80) of gastric carcinoma specimens showed a reduction or absence of E CD expression.Further,the significant correlation was observed between low E CD expression and cellular differentiation( P <0 01) and infiltrative type of gastrie cancer( P <0 01).No significant correlation was found between E CD expression and the depth of invasion,venous and lymphatic vessel invasion,( P >0 05).Conclusions:The expression of E CD could determine the growth pattern and degree of cell differentiation of gastrie cancer.There might be no correlation between E CD expression and the invasion and metastases of gastrie cancer.