B型利钠肽与肝硬化性心肌病

肝硬化可并发心功能不全,目前认为是肝硬化特有的一种并发症,即肝硬化性心肌病.肝硬化性心肌病往往缺乏临床表现,容易为临床所忽视.B型利钠肽(BNP)是对早期心功能不全敏感性很高的神经内分泌激素,可早期预测心肌损伤和心功能不全.肝硬化时血浆BNP水平增高,与肝硬化的疾病严重程度相关,并预示了肝硬化性心肌病的存在.检测肝硬化患者的血浆BNP浓度,有利于早期发现肝硬化性心肌病的存在,以便早期进行预防和处理.

B-type natriuretic peptide and cirrhotic cardiomyopathy

Cirrhosis can be complicated with cardiac dysfunction which,now considered unique to cirrhosis,is called cirrhotic cardiomyopathy.Cirrhotic cardiomyopathy is easily overlooked clinically often owing to the lack of clinical manifestations.The B-type or brain natriuretic peptide(BNP),a neuroendocrine hormones highly sensitive to early cardiac dysfunction,is a strong predictor of heart failure,myocardial injury and cardiac dysfunction.Moreover,increased plasma BNP levels in patients with cirrhosis are correlated with the severity of liver disease and can indicate the existence of cirrhotic cardiomyopathy.Therefore,the detection of plasma BNP levels is conducive to early detection,prevention and treatment of cirrhotic cardiomyopathy.