马齿苋水提取物抗炎作用研究

观察马齿苋水提取物（ WEPO）的抗炎作用，为其临床应用提供实验依据。方法：昆明种小鼠50只，随机分为空白对照组，WEPO 大、中、小剂量组（20g/kg，10g/kg，5g/kg）和阿司匹林200mg/kg组。采用二甲苯致小鼠耳廓肿胀法，以小鼠耳肿胀度为指标，评价WEPO 的抗炎作用。结果：WEPO大、中、小剂量组小鼠耳肿胀度分别为1．51±0．38mg，1．95±0．48mg和2．61±0．77mg，显著低于空白对照组4．70±0．68mg，差异有统计学意义（P＜0．01），WEPO大剂量组与阿司匹林组耳肿胀度（2．22±0．58mg）比较，差异无统计学意义（ P＞0．05）。结论：马齿苋水提取物有明显的抗炎作用且呈剂量依赖性。

Anti-inflammatory Effect of Water Extract of Portulaca Oleracea L

To evaluate anti-inflammatory activity of water extract of portulaca oleracea L （ WEPO） and provide scientific basis for its clinical application .Method：50 Kunming mice were randomly divided into normal group , 20g/kg,10g/kg,5g/kg dose groups of P .oleracea and aspirin group （ 200mg/kg dose ） .The effect of water extract of P .oleracea was observed by xylene-induced ear edema test .Result：Ears edema in high, medium and low -dose groups were 1.51±0.38mg,1.95±0.48mg and 2.61±0.77mg re-spectively and they were lower than 4.70±0.68mg in control group （P〈0.01）.The water extract of P.olera-cea significantly inhibited xylene-induced ear edema and had dose dependence .WEPO 20g/kg group had same anti-inflammatory effect as aspirin（P〉0.05）.Conclusion：The water extract of portulaca oleracea L. has obvious anti-inflammatory effect and has dose dependence .