腹股沟疝病人血清 MMP-2 TIMP-2 TIMP-1锌铜及前胶原末端肽的测定分析

目的：比较血清MMP-2、TIMP-2、TIMP-1、锌、铜及前胶原末端肽的表达，探讨腹股沟疝的发病机制。方法：以在我院行疝修补术患者为研究对象，其中直疝35例；斜疝35例；复发疝17例；正常对照35例。收集各组病人血清标本，对血清指标进行检测。结果：直疝及复发疝组病人血清MMP-2水平显著高于正常组及斜疝组（P＜0．05），尤其为复发疝；血清TIMP-2及TIMP-1水平在直疝和复发疝明显低于正常组及斜疝组（ P＜0．05）；血清铜和锌含量在各组无显著性差异；直疝及复发疝组血清前胶原末端肽PⅠCP/PⅢNP比值显著低于正常组及斜疝组，（ P＜0．05）。结论：和结缔组织代谢相关指标MMP-2、TIMP-2、TIMP-1及PICP/PⅢNP 的改变参与了直疝的发生，并和疝术后复发密切相关。

Study on Serum Concentrations of MMP-2 TIMP-2 TIMP-1 Copper Zinc and Terminal Propeptides of Precollagen in Inguinal Patients with Hernia

Objective：To investigate the expression of MMP-2, TIMP-2, TIMP-1, copper, zinc and terminal propeptides of precollagen in the serum of inguinal hernia and explore the pathogenesis of the dis-ease.Method：The samples were collected from inguinal hernia patients （ direct n=35, indirect n=35, re-current n=17） and from healthy controls （ n=35） .The indicators in serum were measured according to the instruction books of the reagent kits .Result：Serum levels of MMP-2 in direct and recurrent hernia patients were higher than indirect hernia patients and controls （P〈0.05）.TIMP-2 and TIMP-1 were lower（P〈0. 05）.Serum levels of Cu and Zn in four groups （especially the recurrent hernia group） have no significant difference.The results of serum PICP/PⅢNP were lower in direct and recurrent groups compared to indirect group and controls（P〈0.05）.Conclusion：The changes of serum MMP-2, TIMP-2, TIMP-1 and PICP/PⅢNP might be associated with the development of direct and recurrent inguinal hernia .