大肠癌 p21蛋白和雌激素受体表达 与预后的关系

目的探讨p21蛋白和雌激素受体（estrogenreceptor,ER）在大肠癌中的表达及其与大肠癌临床生物学行为的关系。方法采用免疫组织化学方法（LSAB）,对206例大肠癌标本分别进行p21蛋白和ER表达的检测,并结合临床资料进行分析。结果大肠癌p21蛋白的表达与ER的表达具有明显负相关（r=-0.6613,P<0.01）。p21蛋白及ER的表达与患者年龄、性别、肿瘤部位、大体类型、组织类型、Dukes'分期等无关（r<0.4,P>0.05）;与患者预后明显相关（P<0.01）,即p21表达水平越高患者预后越差,而ER的表达水平越高则患者预后越好。结论大肠癌p21蛋白的异常表达可能与雌激素代谢紊乱有关,p21蛋白和ER表达的检测有助于大肠癌的临床诊断及预后的评估。

Expression and Prognostic Values of p21 Protein and Estrogen Receptor in Colorectal Cancers

Objective： This study was designed to explore the relationship between clinicobiological acting and expression of p21 protein and estrogen receptor(ER) in colorectal cancer. Methods： The intensity of expression of p21 protein and ER for 206 patients with colorectal cancers were determined by labeled-streptokinase avidin-biotin(LSAB) assay. Results： The expression of p21 protein is negatively correlated with that of ER in colorectal cancer(r=-0.6613, P<0.01). The intensity of expression of p21 protein and ER in colorectal cancers were not related with the patients age, sexuality, tumor position, pathological type, histological type, Dukes stage etc.(r< 0.4,P>0.05). Both the expressions were related to the prognosis of colorectal cancer(P<0.01). Higher the intensity of expression of p21 protein worse the patients prognosis, and higher the intensity of expression of ER better the patient s prognosis. Conclusions： The abnormal expression of p21 protein is related to the dysbolism of estrogen in colorectal cancer. The detection of p21 protein and ER are helpful for diagnosis and prognostic evaluation for colorectal cancer.