| 口腔颌面部淋巴管畸形的VEGF-C和VEGFR-3表达 |
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| 引用本文： | 刘斌,张文峰,赵怡芳. 口腔颌面部淋巴管畸形的VEGF-C和VEGFR-3表达[J]. 口腔医学研究, 2004, 20(4): 389-391 |
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| 作者姓名： | 刘斌 张文峰 赵怡芳 |
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| 作者单位： | 武汉大学口腔医学院口腔颌面外科,湖北,武汉,430079 |
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| 摘 要： | 目的 :观察接受和未接受平阳霉素治疗的淋巴管畸形中VEGF -C和VEGFR - 3表达 ,探讨平阳霉素治疗淋巴管畸形机制。方法 :收集 2 0例接受平阳霉素治疗的淋巴管畸形标本及 10例未接受治疗的标本做组织学观察以及免疫组织化学研究 ,评价形态学变化并分析VEGF -C和VEGFR - 3表达是否存在差异。结果 :两组病变VEGF -C和VEGFR - 3表达有显著性差异 (P <0 .0 5 ) ,并且VEGF -C和VEGFR - 3表达有相关性。结论 :平阳霉素注射治疗淋巴管畸形的分子机制可能是通过抑制VEGF -C -VEGFR - 3系统的信号传导从而达到治疗淋巴管畸形的目的
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| 关 键 词： | 平阳霉素 淋巴管畸形 VEGF-C VEGFR-3 |
| 文章编号： | 1671-7651(2004)04-0389-03 |
| 修稿时间： | 2003-11-06 |
The Expressions of VEGF-C and VEGFR-3 in Lymphatic Malformations |
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| LIU Bin,ZHANG Wen-feng,ZHAO Yi-fang. School of Stomatology,Wuhan University,Wuhan. The Expressions of VEGF-C and VEGFR-3 in Lymphatic Malformations[J]. Journal of Oral Science Research, 2004, 20(4): 389-391 |
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| Authors: | LIU Bin ZHANG Wen-feng ZHAO Yi-fang. School of Stomatology Wuhan University Wuhan |
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| Affiliation: | LIU Bin,ZHANG Wen-feng,ZHAO Yi-fang. School of Stomatology,Wuhan University,Wuhan 430079 |
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| Abstract: | Objective: To observe the expressions of VEGF-C and VEGFR-3 in both the lymphatic malformations treated by pingyangmycin and those without the treatment in order to explore the mechanism of the treatment. Methods: 20 specimens with the treatment and 10 specimens without the treatment were collected, which were taken for histological observation and stained by immunohistochemical method. Results: There were significant difference and correlation between the expression of VEGF-C and that of VEGFR-3 in the two situations(P<0.05). Conclusion: Blocking the signal of VEGF-C-VEGFR-3 is the possible molecular mechanism of the treatment. |
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| Keywords: | Pingyangmycin Lymphatic malformation VEGF-C VEGFR-3 |
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