冠心病患者血浆内皮素－1和血清C型利钠肽、胱抑素C、妊娠相关血浆蛋白A水平变化及其临床意义

目的：探讨冠心病患者血浆内皮素－1（ ET－1）和血清C型利钠肽（ CNP）、胱抑素C、妊娠相关血浆蛋白A （ PAPPA）水平变化及其临床意义。方法选择我院心内科2012年6月—2013年6月收治的冠心病患者91例为冠心病组，其中稳定型心绞痛（ SAP）患者35例（ SAP组）、不稳定型心绞痛（ UAP）患者33例（ UAP组）、急性心肌梗死（ AMI）患者23例（ AMI组）；选择同期在我院体检健康者35例为对照组。检测所有受试者血浆ET－1和血清CNP、胱抑素C、 PAPPA水平，并进行比较。结果冠心病组患者血浆ET－1和血清CNP、胱抑素C、 PAPPA水平均高于对照组（ P＜0.05）。 SAP组、 UAP组、 AMI组血浆ET－1和血清CNP、胱抑素C、 PAPPA水平均高于对照组， UAP组、 AMI组均高于SAP组， AMI组高于UAP组（P＜0.05）。直线回归分析结果显示，冠心病患者血清PAP-PA水平与血浆ET－1（r＝0.592）和血清CNP （r＝0.602）、胱抑素C （r＝0.593）水平均呈正相关（P＜0.01）。结论冠心病患者血浆ET－1和血清CNP、胱抑素C、 PAPPA水平明显升高，且随着冠心病严重程度加重而升高。

Changes and Clinical Significance of Plasma ET-1 Level,Serum CNP,Cystatin C and PAPPA Levels in Patients with Coronary Heart Disease

Objective To investigate the changes and clinical significance of plasma ET -1 level, serum CNP, Cys-tatin C and PAPPA levels in patients with coronary heart disease （CHD）.Methods From June 2012 to June 2013, 91 patients with CHD were selected as CHD group in our hospital , thereinto 35 patients with SAP were served as SAP group , 33 patients with UAP as UAP group, 23 patients with AMI as AMI group; at the same time, 35 healthy cases were selected as control group.Plasma ET-1 level, serum CNP, Cystatin C and PAPPA levels were detected and compared .Results Plasma ET-1 level, serum CNP, Cystatin C and PAPPA levels of CHD group were higher than those of control group （P〈0.05）, and those of SAP group, UAP group, AMI group were higher than those of control group , those of UAP group, AMI group were higher than those of SAP group , those of AMI group were higher than those of UAP group （ P〈0.05 ） .Linear regression analysis showed that, serum PAPPA level was positively correlated with serum plasma ET -1 level （r=0.592）, serum CNP level （r=0.602） and serum Cystatin C level （r=0.593） in patients with CHD, the differences were statistically significantly different （P〈0.05）.Conclusion Plasma ET-1 level, serum CNP, Cystatin C and PAPPA levels are higher in patients with CHD , and elevates with severity of CHD .