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| Prolonged cholestasis after raloxifene and fenofibrate interaction： A case report | |
| 引用本文： | Lucena MI,Andrade RJ,Vicioso L,González FJ,Pachkoria K,García-Muñoz B. Prolonged cholestasis after raloxifene and fenofibrate interaction： A case report[J]. World journal of gastroenterology : WJG, 2006, 12(32): 5244-5246. DOI: 10.3748/wjg.v12.i32.5244 |
| 作者姓名： | Lucena MI Andrade RJ Vicioso L González FJ Pachkoria K García-Muñoz B |
| 作者单位： | Clinical Pharmacology Service Virgen de la Victoria University Hospital School of Medicine,Malaga,Spain,Liver Unit Gastroenterology Service,Virgen de la Victoria University Hospital,School of Medicine,Málaga,Spain,Department of Pathology Virgen de la Victoria University Hospital,School of Medicine,Málaga,Spain,Institute of Biopathology and Regenerative Medicine University of Granada,Spain,Clinical Pharmacology Service Virgen de la Victoria University Hospital,School of Medicine,Málaga,Spain,Liver Unit Gastroenterology Service,Virgen de la Victoria University Hospital,School of Medicine,Málaga,Spain |
| 基金项目： | Supported by a research grant from the Agencia Espanola del Medicamento and Fondo de Investigaciones Sanitarias, No. FIS PI 04/1759 and PI 04/1688 |
| 摘 要： | Assigning causality in drug-induced liver injury is challenging particularly when more than one drug could be responsible. We report a woman on long-term therapy with raloxifen who developed acute cholestasis shortly after starting fenofibrate. The picture evolved into chronic cholestasis. We hypothesized that an interaction at the metabolic level could have triggered the presentation of hepatotoxicity after a very short time of exposure to fenofibrate in this patient. The findings of an overexpression of vascular endothelial growth factor in the liver biopsy suggest that angiogenesis might play a role in the persistance of toxic cholestasis. |
| 关 键 词： | 慢性胆汁淤积 非诺贝特 肝中毒 病理机制 |
| 收稿时间： | 2006-02-15 |
Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report |
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| Lucena M Isabel,Andrade Raúl J,Vicioso Luis,González F Jesús,Pachkoria Ketevan,García-Muñoz Beatriz. Prolonged cholestasis after raloxifene and fenofibrate interaction: A case report[J]. World journal of gastroenterology : WJG, 2006, 12(32): 5244-5246. DOI: 10.3748/wjg.v12.i32.5244 | |
| Authors: | Lucena M Isabel Andrade Raúl J Vicioso Luis González F Jesús Pachkoria Ketevan García-Muñoz Beatriz |
| Affiliation: | 1. Clinical Pharmacology Service, Virgen de la Victoria University Hospital, School of Medicine, Málaga, Spain 2. Liver Unit, Gastroenterology Service, Virgen de la Victoria University Hospital,School of Medicine, Málaga, Spain 3. Department of Pathology, Virgen de la Victoria University Hospital, School of Medicine, Málaga, Spain 4. Institute of Biopathology and Regenerative Medicine, University of Granada, Spain |
| Abstract: | Assigning causality in drug-induced liver injury is challenging particularly when more than one drug could be responsible. We report a woman on long-term therapy with raloxifen who developed acute cholestasis shortly after starting fenofibrate. The picture evolved into chronic cholestasis. We hypothesized that an interaction at the metabolic level could have triggered the presentation of hepatotoxicity after a very short time of exposure to fenofibrate in this patient. The findings of an overexpression of vascular endothelial growth factor in the liver biopsy suggest that angiogenesis might play a role in the persistance of toxic cholestasis. |
| Keywords: | Raloxifene Fenofibrate Drug-drug interactions Hepatotoxicity Causality assessment |
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